ERYTHROMYCIN LACTOBIONATE PACKAGE INSERT PDF

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Erythromycin Lactobionate 1g Powder for Solution for Infusion – Summary of Product Characteristics (SmPC) by ADVANZ Pharma. Erythromycin Lactobionate I.V. is a sterile presentation of erythromycin. It is not When administering the product by intermittent infusion do not use solution strengths greater than . includes any possible side effects not listed in this leaflet. Intravenous infusion of mg of erythromycin lactobionate at a constant rate physiologically concentrated or in situations where high dosage of drug can be.

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Dosage Information in more detail. The inseft should be completed within 8 hours of preparation to ensure potency. There are no adequate and well-controlled studies in pregnant women. This may result in QTc prolongation and cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation and torsades de pointes. As with other macrolides, rare serious allergic reactions, including acute generalised exanthematous pustulosis AGEP have been reported.

Ear and labyrinth disorders: Medically reviewed on Sep 5, The same applies for streptomycin, tetracyclines and colistin. Erythrocin Lactobionate Rating No reviews – Add your review.

Caution should be exercised when administering erythromycin to lactating mothers due reports of infantile hypertrophic pyloric stenosis in breast-fed infants.

There have been post-marketing reports of colchicine toxicity with concomitant use of erythromycin and colchicine. Prolonged QTc interval and ventricular arrhythmias have been reported rarely in patients receiving intravenous erythromycin. Erythromycin Lactobionate 1g Powder for Solution for Infusion. If you think there packate been an overdose, call your poison control center or get medical care right away.

The most frequent side effects of oral erythromycin preparations are gastrointestinal and are dose-related. For Continuous Infusion of 1 gram dose: Post-marketing reports indicate that co-administration of erythromycin with ergotamine or dihydroergotamine has been associated with acute ergot toxicity characterised by vasospasm and ischaemia of the central nervous system, extremities and other tissues see section 4.

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Physicians should be aware that reappearance of the allergic symptoms may occur when symptomatic therapy is discontinued. Bolus injection is not recommended. Erythromycin significantly alters the metabolism of terfenadine, astemizole and pimozide when taken concomitantly. As a result of this plasma levels of active steroid may decrease. Do not start, stop, or change the dose of any drug without checking with your doctor.

Erythromycin is excreted principally by the liver, so caution should be exercised in administering the antibiotic to patients with impaired hepatic function or concomitantly receiving potentially hepatotoxic agents.

The following have been reported: GranulesErycErythromycin has been reported to decrease the clearance of zopiclone and thus may increase the pharmacodynamic effects of this drug. However, many people have no side effects or only have minor side effects. There have been reports of infantile hypertrophic pyloric stenosis IHPS occurring in infants following erythromycin therapy.

Lower Respiratory Tract infections: Following intravenous infusion, erythromycin is widely distributed throughout body tissues, including lung tissues. Erythromycin exerts its antimicrobial action by binding to the 50S ribosomal sub-unit of susceptible microorganisms and suppresses protein synthesis. For further details please see section 6.

Erythromycin Lactobionate – I.V.

Continuous infusion of this medicine is preferred due to the slower infusion rate and lower concentration of erythromycin; however, intermittent infusion at intervals not greater than every six hours is also effective.

Benzyl alcohol may be added as a preservative. Deafness, tinnitus There have been isolated reports of reversible hearing loss occurring chiefly in patients with renal insufficiency or taking high doses. Lactlbionate view content sources and attributions, please refer to our editorial policy.

Erythromycin Lactobionate 1g Powder for Solution for Infusion

If an allergic reaction occurs, the drug should be discontinued and appropriate therapy should be instituted. Rhabdomyolysis with or without renal impairment has been reported in seriously ill patients receiving erythromycin concomitantly with statins.

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Since erythromycin may be used in the treatment of conditions in infants which are associated with significant mortality or morbidity such as pertussis or chlamydiathe benefit of erythromycin therapy needs to be weighed against the potential risk of developing IHPS.

There have been reports suggesting erythromycin does not reach the foetus in adequate concentrations to prevent congenital syphilis. Erythromycin use in patients who are receiving high doses of theophylline may be latobionate with an increase in serum theophylline levels and potential theophylline toxicity. Enter medicine name or company Start typing to retrieve search suggestions. Find out more here. Particular care should be taken with medications known to prolong the QTc interval of the electrocardiogram.

Tell your doctor and pharmacist about all of your drugs erythromycln or OTC, natural products, vitamins erythromycn health problems.

Erythromycin should not be used during and two weeks after treatment with CYP3A4 inducers. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:. However, observational studies in humans have reported cardiovascular malformations after exposure to medicinal products containing erythromycin during early pregnancy. Side effects in more detail.

Erythromycin Lactobionate – I.V. Information –

This information is intended for use by health professionals. QTc interval prolongation, torsades de pointes, palpitations, and cardiac rhythm disorders including ventricular tachyarrhythmias.

Last updated on eMC: Allergic reactions ranging from urticaria and mild skin eruptions to anaphylaxis have occurred.