Chlorothiazide should be used cautiously in patients with renal disease resulting in severe renal impairment because the drug decreases the glomerular. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Diuril (Chlorothiazide). Chlorothiazide sodium for injection, USP is a diuretic and a vial containing: Chlorothiazide sodium equiva- . toxicity. Refer to the package insert for lithium.

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Moderate Acetazolamide promotes electrolyte excretion including hydrogen ions, sodium, and potassium.

Moderate Coadministration of thiazide diuretics and antineoplastic agents such as cyclophosphamide may result in reduced renal excretion of the antineoplastic agent and therefore increased myelosuppressive effects. If treatment with lithium and a thiazide diuretic cannot be avoided, patients should have their serum lithium concentrations closely monitored, and the lithium dosage adjusted if necessary.

Related Drug Information Drug Diruil. Minor Monitor potassium and magnesium levels when thiazide diuretics are used during ziprasidone therapy. Therefore, when chlorothiazide sodium and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

After oral administration, diuresis begins within 2 hours, peaks in about 4 hours and lasts about 6—12 hours. Moderate Ibuprofen lysine may reduce the effect of diuretics; diuretics can increase the risk of nephrotoxicity of NSAIDs in dehydrated patients.

Akorn – Sodium Diuril® (chlorothiazide sodium)

Thus latent diabetes mellitus may become manifest during thiazide therapy. Moderate Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.


In the absence of electrolyte imbalances, these agents can be used together safely with appropriate monitoring; clinicians inserh monitor for evidence of electrolyte disturbances or cardiac-related patient complaints. Infants and Children 6 months to younger than 2 years. In some cases, thiazide diuretics may be used to counteract lithium-induced polyuria, although close monitoring is necessary if such treatment is initiated.

The plasma half-life of chlorothiazide is 45 to minutes.

Dilution Chlorothiazide – GlobalRPH

Moderate Hawthorn, Crataegus laevigata may lower peripheral vascular resistance. Discard unused portion of the reconstituted solution. Anuria, renal disease, renal failure, renal impairment. Lithium generally should not be given with diuretics. During coadministration of NSAIDs and inssrt therapy, patients should be monitored for changes in the effectiveness of their diuretic therapy and for signs and symptoms of renal impairment.

Concurrent use with baclofen and antihypertensive agents may result in additive hypotension.

Discontinuation of escitalopram should be considered in patients who develop symptomatic hyponatremia. Moderate Patients on antihypertensive agents receiving bortezomib treatment may require close monitoring of their blood pressure inaert dosage adjustment of their medication. Moderate Thiazide diuretics can cause decreased arterial responsiveness to norepinephrine, but the effect is not sufficient to preclude their coadministration.

Moderate Additive hypotensive effects may occur when nitroprusside is used concomitantly with other antihypertensive agents. Major In general, antipsychotics like haloperidol should be used cautiously with antihypertensive agents due to the possibility of additive hypotension.


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Atypical antipsychotics may cause orthostatic hypotension and syncope, most commonly during treatment initiation and dosage increases. Patients with impaired renal function eGFR Captopril: Relatively high doses of fish oil are required to produce any blood pressure lowering effect.

Moderate Concurrent use of tizanidine with antihypertensive agents can result in significant hypotension. Moderate Alemtuzumab may cause hypotension.

It is possible that additive reductions in blood pressure may be seen when fish oils are used in a patient already taking antihypertensive agents.

Major Dose adjustment of vitamin D analogs may be necessary during coadministration with thiazide diuretics.

According to the OBRA guidelines, antihypertensive regimens should be individualized to achieve the desired outcome while minimizing adverse effects. Extravasation, intramuscular administration, subcutaneous administration. Major The vasoconstricting actions of oxymetazoline, an alpha adrenergic agonist, may reduce the antihypertensive effects produced by diuretics.

Information on oral dosing in this age group is supported by evidence from empiric use in pediatric patients and published literature regarding the treatment of hypertension in such patients. Concurrent use of citalopram and medications known to cause electrolyte imbalance may increase the risk of developing QT prolongation.

Concomitant administration may potentiate the renal toxicity of mannitol.

Reconstituted solution is stable for 24 hours at room temperature.