The pathophysiology of anemia and the basis of its clinical investigation. Pruebas que evalúan el estado del hierro: Hierro del compartimiento funcional: Ferremia: Capacidad total de saturación de hierro (CTSH). Transcript of Clasificacion de anemias. Disminución de la capacidad transportadora de oxigeno de la sangre. Adaptaciones fisiológicas.

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Classification of anemia for gastroenterologists

In cases of accelerated rbc destruction, the capacity of the liver to capture bilirubin is saturated, and the concentration of unconjugated bilirubin in serum increases, occasionally to the point of producing clinical jaundice.

The yolk sack is the origin of the first generation of erythrocyte precursors. Circula aemias en el plasma en el cual sus niveles oscilan entre 5 y 30 microgrs. Epidemiologia Se estima que la incidencia de la pitiriasis rosada es de alrededor de por Laboratory measurement of haptoglobin is fairly easy and yields useful information to assist in documenting decreased rbc life span.

Claslficacion “purpose” of this reaction is to keep the kidneys from squandering iron free hemoglobin is freely filtered by the glomerulus, but hemoglobin-haptoglobin complexes are too big to muscle their way through, so that they are safe to bumble their way back to the reticuloendothelial system where they can be properly disassembled.

Anemia may exist as a laboratory finding in a subjectively healthy individual, because the body can, within limits, compensate for the decreased red cell mass. Iron deficiency is the most common cause of anemia, so the first step in diagnosis should be directed toward confirmation or exclusion of IDA.


To avoid these confounding events, it is recommended to calculate the reticulocyte index. The hemogram, the concentration of iron, ferritin and transferrin in blood and investigation of fecal occult blood are sufficient to obtain a diagnosis in most cases. Making clinical decisions based on this raw count is somewhat fallacious.

Serum ferritin allows us to confirm the diagnosis. Table 2 Morphological classification. How to interpret and pursue an abnormal complete blood cell count in adults. Bone marrow biopsy This can be used to directly observe any accelerated production of rbc’s. Some infectious or parasitic diseases that are diagnosed with relative frequency are: Diagnosis of megaloblastic anemia.

The most likely causes of normocytic anemia are ACD, renal failure and primitive hematological diseases least frequently. These are the hyporegenerative anemias. Reticulocyte count A sample of blood is stained with a supravital dye that marks reticulocytes. To complete the study of vitamin B12 deficiency, it is necessary to look for antibodies to intrinsic factor, which if positive, confirms the diagnosis of pernicious anemia.

Moreover, anemia is one of the leading sings in many diseases or is the first evidence of disease observed in routine blood cell enumeration. Epidemiology of anemia in human immunodeficiency virus HIV -infected persons: Hypo-regenerative anemia This is clasiificacion by alteration of bone marrow progenitor cells, which can be located at different anemiias of differentiation and maturation.

The sings of anemia include pallor of the conjunctivae, face, nail beds and palmar creases, although the absence of pallor does not rule out anemia[ 4 ]. The classic example is aplastic anemiadee which there is primary marrow failure to produce enough erythrocyte mass.


This occurs when there is rapid hemorrhage, with red cells and plasma being rapidly lost clasificacio, before the body can respond by hiking up the plasma volume. En la tabla I se resumen las causas de deficiencia de vitamina B In these cases, the marrow responds appropriately to anemia by briskly stepping up the production of rbc’s and releasing them into the bloodstream prematurely.

Anemia: Pathophysiology, Classification, Clinical Investigation

Backwell Scientific Publication; The next step is the calculation of reticulocyte production index RPI: With these key data, the doctor can put in place more specific tests: Clearly, one needs to find some way to correct the raw retic count ed as to avoid this problem. Transferrin saturation index; MCV: F reticulocyte maturation times in vivo RPI in a healthy person is 1.

Small-bowel inflammatory disease is a widespread cause of chronic disease anemia. It is observed in patients that have immune hyperactivity. Prospective survey of investigations in outpatients referred with iron deficiency anaemia.

The MCH concentration MCHC reports on the average concentration of hemoglobin in each erythrocyte expressed as a percentage normal range: Synchronous upper and lower gastrointestinal endoscopy is an effective method of investigating iron-deficiency anaemia.